The Victorian-era Thistle Piccadilly is on the corner of Coventry Street, one block from Piccadilly Circus, and approximately 30 miles from London Heathrow Airport. This location is also two blocks from Soho, one mile from the London Eye and Houses of Parliament, two miles from Regents Park and Royal Albert Hall, three miles from the Natural History Museum, four miles from Olympia, and nine miles from Wembley.

Hotel amenities include Cupids Bar. The hotel also offers room service, laundry facilities, currency exchange, and a concierge.

All rooms feature air-conditioning, dataports, voicemail, tea/coffee facilities, trouser presses, hairdryers, and satellite TV.