Holiday Inn Express & Suites Cape Girardeau is located approximately two miles from the Mississippi River Wall of Fame Murals and six miles from Cape Girardeau Regional Airport. This location is also a quarter-mile from Westfield Shoppingtowne, one mile from the Osage Center, two miles from Southeast Missouri State University, 10 miles from Trail of Tears State Park, 20 miles from Bollinger Mills State Historic Site, 130 miles from Lambert International Airport (in Saint Louis), and 150 miles from Memphis International Airport. The property's amenities include the indoor pool, whirlpool, fitness room, game room, and complimentary continental breakfast. The hotel also offers high-speed Internet access, valet laundry service, and free parking. All rooms feature cable TV, in-room movies, free local calls, coffee/tea facilities, refrigerators, microwaves, and hairdryers.