At the banks of the river Main, Frankfurt InterContinental is approximately one mile from Old Town and eight miles from Frankfurt International Airport. This location is also half a mile from Museum Mile and the Senckenberg Museum, two miles from Plamengarten and Frankfurt Zoo, three miles from Hoechst Castle, and 22 miles from Rheingau and Wiesbaden.

Hotel amenities include the fitness center, gift shop, concierge, DAXx Mainhattan's Bar (with live music everyday but Sunday), and two restaurants. Signatures Veranda Restaurant has Euro-Asian cuisine, while Leon's serves Italian and American fare. The hotel also offers room service, babysitting, valet laundry service, currency exchange, and porters.

All rooms feature cable TV, in-room movies, high-speed Internet access, desks, coffeemakers, minibars, irons and ironing boards, hairdryers, bathrobes, free weekday newspapers, safes, voicemail, sofa beds, trouser pressers, and individual climate control.