San Clemente Palace is a converted 17th-century Camaldolesi monastery located on the private, 17-acre island of San Clemente, approximately 45 minutes from Marco Polo Airport. This location is also 15 minutes from Saint Mark's Square by the hotel's free 24-hour shuttle boat.

Hotel amenities include the seasonal lagoon-view pool, tennis courts, health/beauty spa, and four acres of gardens. The spa offers aromatherapy, body treatments, facials, massage, and hair and nail care. It includes a steam room, sauna, two spa tubs, and a fitness center. For on-site dining, the hotel offers a complimentary buffet breakfast, Gli Arazzi Ristorante, Ca' dei Frati (fine-dining restaurant with wood-beamed ceiling, terra-cotta-tile floor, and brocade booths), Le Maschere (with Venice Carnival decor theme), La Laguna (outdoor spot specializing in grilled foods in summer), Gli Specchi (pub-style food), Le Conchiglie (summertime pool bar), and 24-hour room service.

All rooms feature high ceilings, arched windows, Venetian-theme ambience, area rugs, reading chairs, cocktail tables, work desks, marble bathrooms, hypoallergenic comforters, six pillows, separate tubs and showers, French toiletries, terry-cloth bathrobes and slippers, Internet access, satellite TV, voicemail, complimentary bottled water, minibars, bathroom telephones, bidets, and an in-house music system.